2019/04/26 by Onyinye I. Iweala, Cathryn R. Nagler · 1 citation
Immunology and Microbiology · Medicine · #IL-33, ST2, and ILC Pathways #Food Allergy and Anaphylaxis Research #Asthma and respiratory diseases #Biology #Immune system #Immunology #Microbiome #Innate lymphoid cell #Antigen #Innate immune system #Acquired immune system #Food allergy #Immune tolerance #Homeostasis #Immunity #Gut flora #Allergy #Cell biology #Bioinformatics
paper · doi:10.1146/annurev-immunol-042718-041621
openalex publication_date 2019/04/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
commensal microbes and greater than 30 kg of food proteins yearly. It must distinguish these harmless antigens from potential pathogens and mount the appropriate host immune response. Local and systemic hyporesponsiveness to dietary antigens, classically referred to as oral tolerance, comprises a distinct complement of adaptive cellular and humoral immune responses. It is increasingly evident that a functional epithelial barrier engaged in intimate interplay with innate immune cells and the resident microbiota is critical to establishing and maintaining oral tolerance. Moreover, innate immune cells serve as a bridge between the microbiota, epithelium, and the adaptive immune system, parlaying tonic microbial stimulation into signals critical for mucosal homeostasis. Dysregulation of gut homeostasis and the subsequent disruption of tolerance therefore have clinically significant consequences for the development of food allergy.