Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

2005/10/01 by John Dormandy, John A Dormandy, Bernard Charbonnel +44 · 4,139 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cardiology #Cardiovascular Function and Risk Factors #Clinical endpoint #Diabetes mellitus #Diabetes, Cardiovascular Risks, and Lipoproteins #Endocrinology #Internal medicine #Macrovascular disease #Medicine #Myocardial infarction #Peroxisome Proliferator-Activated Receptors #Pioglitazone #Placebo #Randomized controlled trial #Stroke (engine) #Surgery #Type 2 diabetes

paper · open access · doi:10.1016/s0140-6736(05)67528-9

published in The Lancet 366(9493), 1279-1289 (Elsevier BV)

crossref issued 2005/10/01 · crossref published 2005/10/01 · crossref published-print 2005/10/01 · openalex publication_date 2005/10/01 · crossref created 2005/11/07 · crossref deposited 2019/01/21 · openalex created_date 2025/10/10 · crossref indexed 2026/08/03 · openalex updated_date 2026/08/04

Citations

• Proportional hazards tests and diagnostics based on weighted residuals
• Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

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• Stroke [wikipedia]