1997/11/01 by Sarah B. Coutts, Andrew T. Kicman, Derek T. Hurst +1 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · Chemistry · #Hormonal and reproductive studies #Pharmacology and Obesity Treatment #Muscle metabolism and nutrition #Epitestosterone #Endocrinology #Internal medicine #Dihydrotestosterone #Testosterone (patch) #Urinary system #Hormone #Luteinizing hormone #Chemistry #Alpha (finance) #Androgen #BETA (programming language) #Basal (medicine) #Medicine #Surgery
paper · pdf · doi:10.1093/clinchem/43.11.2091
openalex publication_date 1997/11/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/05/21
A recommended confirmatory procedure for detecting 5 alpha-dihydrotestosterone (DHT) doping in male athletes proposed the use of the urinary concentration ratio of DHT to epitestosterone (EpiT) as the primary marker and those of 5 alpha-androstane-3 alpha,17 beta-diol (5 alpha-Adiol) to EpiT, luteinizing hormone (LH), and 5 beta-androstane-3 alpha,17 beta-diol (5 beta-Adiol) as secondary markers. Here we investigate the effects on these markers of intramuscular administration of DHT heptanoate (250 mg) to six healthy men. Within 24 h of administration all four markers greatly exceeded the published discrimination limits, remaining above these limits for 10-14 days. All ratios returned to basal values by day 28. In contrast to results after percutaneous administration, 5 beta-Adiol excretion decreased, probably as a consequence of greater suppression of testicular steroidogenesis. Results were largely in agreement with those obtained after percutaneous administration, although probably augmented by the larger dose and the different route of delivery.