2019/10/03 by Benedikte Paulsen, Hanne Skille, Erin N. Smith +7 · 1 citation
Medicine · #Venous Thromboembolism Diagnosis and Management #Blood properties and coagulation #Blood Coagulation and Thrombosis Mechanisms #Medicine #Internal medicine #Cancer #Hazard ratio #Cohort #Incidence (geometry) #Confidence interval #Population #Proportional hazards model #Gastroenterology #Cohort study #Venous thromboembolism #Surgery #Thrombosis
paper · pdf · doi:10.3324/haematol.2019.224279
openalex publication_date 2019/10/03 · openalex created_date 2019/10/10 · openalex updated_date 2026/07/22
Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of VTE. Cases with incident VTE (n=640) and a randomly selected age-weighted sub-cohort (n=3,734) were derived from a population-based cohort (the Tromsø study). Cox-regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for VTE according to categories of cancer and FGG. In those without cancer, homozygosity at the FGG variant was associated with a 70% (HR 1.7, 95% CI: 1.2–2.3) increased risk of VTE compared to non-carriers. Cancer patients homozygous for the FGG variant had a two-fold (HR 2.0, 95% CI: 1.1–3.6) higher risk of VTE than cancer patients without the variant. Moreover, the six-months cumulative incidence of VTE among cancer patients was 6.4% (95% CI: 3.5–11.6) in homozygous carriers of FGG and 3.1% (95% CI: 2.3–4.7) in those without risk alleles. A synergistic effect was observed between rs2066865 and active cancer on the risk of VTE (synergy index: 1.81, 95% CI: 1.02–3.21, attributable proportion: 0.43, 95% CI: 0.11–0.74). In conclusion, homozygosity at the FGG variant and active cancer yielded a synergistic effect on the risk of VTE.