2015/02/28 by DD Myers · 1 citation
Medicine · #Venous Thromboembolism Diagnosis and Management #Blood Coagulation and Thrombosis Mechanisms #Diagnosis and Treatment of Venous Diseases #Medicine #Thrombosis #Venous thrombosis #Thrombus #Pathophysiology #Coagulation #Blood stasis #Intensive care medicine #Venous stasis #Cardiology #Pathology #Internal medicine
paper · doi:10.1177/0268355515569424
openalex publication_date 2015/02/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
In this chapter, an overview of some of the prominent risk factors that contribute to the pathophysiology of venous thrombosis will be discussed. In 1856, Dr Rudolf Virchow developed the concept outlining the genesis of intravascular thrombosis. Dr Virchow hypothesized that circulatory stasis due to interrupted blood flow, changes in the blood leading to blood coagulation, and irritation or damage to the vascular endothelium would initiate acute venous thrombus generation. Presently, it is known that these above-mentioned risk factors are influenced by increasing age, gender, and obesity. The current chapter will focus on recent preclinical and clinical investigations that will give the reader insight into the prothrombotic mechanisms that lead to acute venous thrombosis.