1996/06/20 by P Tibbles, John Edelsberg · 1,003 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Chemistry · #Diabetic Foot Ulcer Assessment and Management #Oral health in cancer treatment #Blood disorders and treatments #Hyperbaric oxygen #Oxygen #Medicine #Arterial oxygen tension #Oxygen tension #Pure oxygen #Anesthesia #Oxygen pressure #Hyperbaric oxygenation #Oxygen therapy #Oxygen toxicity #Internal medicine #Chemistry
paper · doi:10.1056/nejm199606203342506
published in New England Journal of Medicine 334(25), 1642-1648 (Massachusetts Medical Society)
openalex publication_date 1996/06/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Hyperbaric oxygen — 100 percent oxygen at two to three times the atmospheric pressure at sea level — can result in arterial oxygen tension in excess of 2000 mm Hg1 and oxygen tension in tissue of almost 400 mm Hg.2,3 Such doses of oxygen have a number of beneficial biochemical, cellular, and physiologic effects, and today there are 259 hyperbaric facilities in the United States with 344 single-occupant (“monoplace”) hyperbaric-oxygen chambers.4 In this article, we review the mechanisms of action, evidence of clinical efficacy, and risks of therapy with hyperbaric oxygen.Physiologic EffectsFor hyperbaric oxygen, pressure is expressed . . .