1992/06/01 by Stephen R. Thom · 1 citation
Chemistry · Agricultural and Biological Sciences · #Free Radicals and Antioxidants #Electrochemical Analysis and Applications #Insect and Pesticide Research #Chemistry #Radical #Hypoxanthine #Inert gas #Photochemistry #Singlet oxygen #Inert #Hydroxyl radical #Superoxide #Oxygen #Xanthine oxidase #Superoxide radical #Phenazine #Organic chemistry
paper · pdf · doi:10.1016/0003-9861(92)90532-2
openalex publication_date 1992/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Two free radical generating systems, xanthine oxidase/hypoxanthine or phenazine methosulfate/NADH, were exposed to air plus He, N2, or Ar at partial pressures ranging from 0.2 to 6.0 MPa, and the rates of production of superoxide, hydroxyl, singlet O2, and H2O2 were measured. All three inert gases acted similarly to enhance the production of superoxide radicals by facilitating interactions between iron and H2O2, or O2 and organic radicals. These reactions occurred at quite low gas partial pressures, only 0.28 MPa, and hydrostatic pressures of up to 6.0 MPa had no effect on radical reactions. Enhanced radical production may be the basis for the inhibition of cellular growth mediated by inert gases, and inert gas enhancement of O2 toxicity.