2004/12/03 by Christopher D. Snow, Eric J. Sorin, Young Min Rhee +1 · 4 citations
Biochemistry, Genetics and Molecular Biology · Materials Science · Chemistry · Engineering · #Protein Structure and Dynamics #Enzyme Structure and Function #RNA and protein synthesis mechanisms #Protein folding #Folding (DSP implementation) #Kinetics #Statistical physics #Thermodynamics #Computer science #Chemistry #Physics #Engineering #Classical mechanics
paper · doi:10.1146/annurev.biophys.34.040204.144447
openalex publication_date 2004/12/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Simulation of protein folding has come a long way in five years. Notably, new quantitative comparisons with experiments for small, rapidly folding proteins have become possible. As the only way to validate simulation methodology, this achievement marks a significant advance. Here, we detail these recent achievements and ask whether simulations have indeed rendered quantitative predictions in several areas, including protein folding kinetics, thermodynamics, and physics-based methods for structure prediction. We conclude by looking to the future of such comparisons between simulations and experiments.