1972/06/01 by Friedrich K. Stephan, Irving H. Zucker · 4 citations
Neuroscience · Medicine · #Circadian rhythm and melatonin #Sleep and Wakefulness Research #Regulation of Appetite and Obesity #Circadian rhythm #Entrainment (biomusicology) #Rhythm #Light effects on circadian rhythm #Locomotor activity #Nocturnal #Hypothalamus #Biology #Neuroscience #Endocrinology #Internal medicine #Suprachiasmatic nucleus #Medicine
paper · doi:10.1073/pnas.69.6.1583
openalex publication_date 1972/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats. The generation of 24-hr behavioral rhythms and the entrainment of these rhythms to the light-dark cycle of environmental illumination may be coordinated by neurons in the suprachiasmatic region of the rat brain. Destruction of the medial preoptic area had no effect on 24-hr drinking rhythms.