Hepatoprotective effects ofS-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

2010/01/01 by Arthur I. Cederbaum · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · Chemistry · #Folate and B Vitamins Research #Alcohol Consumption and Health Effects #Sulfur Compounds in Biology #Methionine #Liver injury #CYP2E1 #Glutathione #Alcohol #Metabolite #Pharmacology #Hepatocyte #In vivo #Cytochrome P450 #Chemistry #Alcoholic liver disease #Cirrhosis #Methylation #Biochemistry #Medicine #Biology #In vitro #Internal medicine #Enzyme #Gene

paper · pdf · doi:10.3748/wjg.v16.i11.1366

openalex publication_date 2010/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01

Abstract

S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection.

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• Alcoholic liver disease [wikipedia]

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