Is an Electronic Shield at the Molecular Origin of Lead Poisoning? A Computational Modeling Experiment

2006/12/07 by Christophe Gourlaouen, Olivier Parisel · 1 citation
Chemistry · Engineering · Nursing · Mathematics · #Electrochemical Analysis and Applications #Electrochemical sensors and biosensors #Trace Elements in Health #Shield #Dehydratase #Ion #Function (biology) #Chemistry #Domain (mathematical analysis) #Biophysics #Crystallography #Topology (electrical circuits) #Chemical physics #Materials science #Biology #Cell biology #Biochemistry #Engineering #Gene #Mathematics

paper · doi:10.1002/anie.200603037

openalex publication_date 2006/12/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

Chop and change: Upon substitution of native Zn2+ by exogenous Pb2+ ions in a model of δ-aminolevulinic acid dehydratase, a dramatic change occurs in the topology of the electron localization function at the active site of the protein. This effect is expected to disrupt the natural function of the metalated domain.

Citations

• The Molecular Mechanism of Lead Inhibition of Human Porphobilinogen Synthase
• Low-level lead-induced neurotoxicity in children: an update on central nervous system effects
• ELF: The Electron Localization Function
• Lead and wine. Eberhard Gockel and the colica Pictonum
• A simple measure of electron localization in atomic and molecular systems
• Contaminated and Natural Lead Environments of Man
• The Removal of Lead from Gasoline: Historical and Personal Reflections
• Inorganic Chemistry: Principles of Structure and Reactivity

Cited by

• Lead poisoning [wikipedia]