2011/08/18 by Jean Paulo de Andrade, Strahil Berkov, Françesc Viladomat +3 · 1 citation
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Chemical synthesis and alkaloids #Cholinesterase and Neurodegenerative Diseases #Alkaloids: synthesis and pharmacology #Amaryllidaceae #Alkaloid #Acetylcholinesterase #Amaryllidaceae Alkaloids #Narcissus #Biology #Botany #Chemistry #Traditional medicine #Biochemistry #Medicine #Enzyme
paper · pdf · doi:10.3390/molecules16087097
openalex publication_date 2011/08/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.