1998/01/01 by Eleni Papadopulos‐Eleopulos, Valendar F. Turner, J. M. Papadimitriou +2 · 1 citation
Immunology and Microbiology · Medicine · #Antibody #Antigen #Biology #Gene #Genetics #Genome #HIV Research and Treatment #Herpesvirus Infections and Treatments #Human immunodeficiency virus (HIV) #Immunology #Medicine #Nucleic acid #Plea #RNA #T-cell and Retrovirus Studies #Virology #Virus
paper · doi:10.1185/03007999809113358
openalex publication_date 1998/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/31
SummaryAt present, it is accepted that in 1983 Montagnier proved the existence of HIV. In their 1983 study, Montagnier and his colleagues took the supernatant from cultures containing tissue derived from AIDS patients and banded it in sucrose density gradients. They claimed that the 1.16g/ml band represented purified virus 1. Some of the proteins and RNAs were considered to represent the retroviral proteins and retroviral genome, respectively. Subsequently the proteins were used as antigens for the antibody tests, and the nucleic acids for hybridisation and PCR studies. Indeed, it is logical that if the 1.16 g/ml band contained purified viral-like particles and the particles were infectious, one has no choice but to consider both the proteins and the RNA as being viral constituents.