2001/08/22 by P. L. De Riu, Giulio Rosati, Stefano Sotgiu +1 · 4 citations
Medicine · Neuroscience · #Epilepsy research and treatment #Neuroscience and Neuropharmacology Research #Drug-Induced Ocular Toxicity #Medicine #Epilepsy #Anesthesia #Psychiatry
paper · doi:10.1046/j.1528-1157.2001.0420081084.x
openalex publication_date 2001/08/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
PURPOSE: To report the occurrence of epileptic seizures in humans, closely related to the use of the centrally acting muscle relaxant thiocolchicoside. METHODS: Description of three case histories. RESULTS: Two patients, affected with complex-partial seizures, sometimes secondarily generalized, receiving antiepileptic therapy, were seizure free for 7 and 9 years, respectively. They had the reappearance of tonic-clonic seizures few days after the continued use of thiocolchicoside, at a cumulative dose of the drug of 52 mg and 76 mg, respectively. The third patient was brain damaged and without a history of seizures. He had a sudden, convulsive seizure a few minutes after 4 mg intramuscular thiocolchicoside. CONCLUSIONS: Our case histories indicate that thiocolchicoside has a powerful epileptogenic activity. This drug should be avoided in patients with epilepsy or acute brain injury and possible disruption of the blood-brain barrier.