2014/12/30 by Pengfei Kong, Qingqing Cai, Qirong Geng +4 · 1 citation
Medicine · #Helicobacter pylori-related gastroenterology studies #Antioxidant Activity and Oxidative Stress #Gastric Cancer Management and Outcomes #Medicine #Relative risk #Meta-analysis #Observational study #Vitamin #Cancer #Internal medicine #Cochrane Library #Randomized controlled trial #Vitamin E #Subgroup analysis #Prospective cohort study #Physiology #Gastroenterology #Confidence interval #Biology #Antioxidant #Biochemistry
paper · pdf · doi:10.1371/journal.pone.0116060
openalex publication_date 2014/12/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
AIM: The association between vitamin intake and gastric cancer (GC) has been widely debated due to the relatively weak evidence. In this study, a meta-analysis of prospective and well designed observational studies were performed to explore this association. METHODS: MEDLINE, Cochrane Library, and Sciencedirect were searched for studies of vitamin consumption and gastric cancer. This produced 47 relevant studies covering 1,221,392 human subjects. Random effects models were used to estimate summary relative risk (RR). Dose-response, subgroup, sensitivity, meta-regression, and publication bias analyses were conducted. RESULTS: The RR of gastric cancer in the group with the highest vitamin intake was compared to that of the lowest intake group. Total vitamin intake was 0.78 (95% CI, 0.71-0.83). In 9 studies that individuals were given doses at least 4 times above the tolerable upper intake (UL) vitamins, the RR was 1.20 (95% CI, 0.99-1.44). However, in 17 studies that individuals received doses below the UL, the RR was 0.76 (95% CI, 0.68-0.86). Dose-response analysis was conducted on different increments in different types of vitamins (vitamin A: 1.5 mg/day, vitamin C: 100 mg/day, vitamin E: 10 mg/day) intake with a significant reduction in the risk of gastric cancer, respectively, 29% in vitamin A, 26% in vitamin C, and 24% in vitamin E. CONCLUSION: This meta-analysis clearly demonstrated that low doses of vitamins can significantly reduce the risk of GC, especially vitamin A, vitamin C, vitamin E.