Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?

1995/10/01 by Jane A. Hurst, Richard S. Houlston, Alistair B. Roberts +2 · 2 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Congenital Anomalies and Fetal Surgery #Congenital limb and hand anomalies #Cleft Lip and Palate Research #Medicine #Hypoxia (environmental) #Fetus #Pregnancy

paper · doi:10.1097/00019605-199510000-00013

openalex publication_date 1995/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood flow, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events.

Cited by

• PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase
• Cleft lip and cleft palate [wikipedia]