2012/01/13 by John A. Detre, Hengyi Rao, Danny J.J. Wang +2 · 2 citations
Medicine · Materials Science · Neuroscience · Psychology · #Advanced MRI Techniques and Applications #Lanthanide and Transition Metal Complexes #Cardiac Imaging and Diagnostics #Arterial spin labeling #Magnetic resonance imaging #Medicine #Preclinical research #Perfusion #Neuroimaging #Brain function #Perfusion scanning #Cerebral perfusion pressure #Medical physics #Radiology #Neuroscience #Psychology #Psychiatry
paper · pdf · doi:10.1002/jmri.23581
openalex publication_date 2012/01/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Perfusion provides oxygen and nutrients to tissues and is closely tied to tissue function while disorders of perfusion are major sources of medical morbidity and mortality. It has been almost two decades since the use of arterial spin labeling (ASL) for noninvasive perfusion imaging was first reported. While initial ASL magnetic resonance imaging (MRI) studies focused primarily on technological development and validation, a number of robust ASL implementations have emerged, and ASL MRI is now also available commercially on several platforms. As a result, basic science and clinical applications of ASL MRI have begun to proliferate. Although ASL MRI can be carried out in any organ, most studies to date have focused on the brain. This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care.