1991/11/01 by John W. Belliveau, David N. Kennedy, Robert C. McKinstry +6 · 1 citation
Medicine · Neuroscience · Psychology · #Advanced MRI Techniques and Applications #Functional Brain Connectivity Studies #Advanced Neuroimaging Techniques and Applications #Functional magnetic resonance imaging #Functional magnetic resonance spectroscopy of the brain #Visual cortex #Magnetic resonance imaging #Neuroscience #Stimulus (psychology) #Hemodynamics #Cerebral blood flow #Cerebral cortex #Human brain #Brain mapping #Nuclear magnetic resonance #Blood volume #Medicine #Psychology #Cardiology #Physics #Radiology #Cognitive psychology
paper · doi:10.1126/science.1948051
openalex publication_date 1991/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Knowledge of regional cerebral hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelation between physiological function, energy metabolism, and localized blood supply. A magnetic resonance technique was developed for quantitative imaging of cerebral hemodynamics, allowing for measurement of regional cerebral blood volume during resting and activated cognitive states. This technique was used to generate the first functional magnetic resonance maps of human task activation, by using a visual stimulus paradigm. During photic stimulation, localized increases in blood volume (32 +/- 10 percent, n = 7 subjects) were detected in the primary visual cortex. Center-of-mass coordinates and linear extents of brain activation within the plane of the calcarine fissure are reported.