2017/06/01 by Eliasz Engelhardt, Marleide da Mota Gomes · 1 citation
Medicine · Neuroscience · Psychology · #Parkinson's Disease Mechanisms and Treatments #Genetic Neurodegenerative Diseases #Neurological disorders and treatments #Lewy body #Inclusion bodies #Eosinophilic #Inclusion (mineral) #Pathology #Medicine #Psychoanalysis #Psychology #Disease #Biology #Parkinson's disease
paper · pdf · doi:10.1590/1980-57642016dn11-020012
openalex publication_date 2017/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/19
Fritz Jacob Heinrich Lewy described the pathology of Paralysis agitans [Parkinson disease] and was the first to identify eosinophilic inclusion bodies in neurons of certain brain nuclei, later known as Lewy bodies, the pathological signature of the Lewy body diseases. In 1912, he published his seminal study, followed soon after by an update paper, and 10 years later, in 1923, by his voluminous book, where he exhaustively described the subject. The publication provided extensive information on the pathology of Paralysis agitans, and the entirely novel finding of eosinophilic inclusion bodies, which would become widely recognized and debated in the future. His discovery was acknowledged by important researchers who even named the structure after him. However, after his last publication on the issue, inexplicably, he never mentioned his histopathological discovery again. Despite several hypotheses, the reasons that led him to neglect (reject) the structure which he so preeminently described have remained elusive.