Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

2018/07/26 by Steve Horvath, Junko Oshima, George M. Martin +20 · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Biomarker #Buccal swab #Cord blood #DNA methylation #Epigenetics #Epigenetics and DNA Methylation #Ex vivo #Genetics #Immunology #In vivo #Medicine #Molecular biology #Nuclear Structure and Function #Pathology #Physiology #Premature aging #Progeria #RNA modifications and cancer #dNaM

paper · doi:10.18632/aging.101508

openalex publication_date 2018/07/26 · openalex created_date 2018/08/03 · openalex updated_date 2026/08/04

Abstract

human cell aging assay.

Citations

• Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome
• Accelerated epigenetic aging in Down syndrome
• Phenotype and Course of Hutchinson–Gilford Progeria Syndrome
• Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

Cited by

• Applying blood-derived epigenetic algorithms to saliva: cross-tissue similarity of DNA-methylation indices of aging, physiology, and cognition
• DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples
• Progeria [wikipedia]

Related

• Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome: A Mini-Review
• EpiAge: a next-generation sequencing-based ELOVL2 epigenetic clock for biological age assessment in saliva and blood across health and disease
• The Mutant Form of Lamin A that Causes Hutchinson-Gilford Progeria Is a Biomarker of Cellular Aging in Human Skin
• Hutchinson–Gilford Progeria Syndrome, Aging, and the Nuclear Lamina
• Aggregating Epigenetic Clocks to Study Human Capital Formation