2000/04/01 by James E. Everhart, Deanna Kruszon‐Moran, Guillermo I. Perez‐Perez +2 · 361 citations
Medicine · #Antibody #Confidence interval #Demography #Environmental health #Eosinophilic Esophagitis #Epidemiology #Ethnic group #Gerontology #Helicobacter pylori #Helicobacter pylori infection #Helicobacter pylori-related gastroenterology studies #Immunology #Internal medicine #Medicine #Microscopic Colitis #Multivariate analysis #National Health and Nutrition Examination Survey #Odds ratio #Population #Serology #Seroprevalence #Young adult
paper · pdf · doi:10.1086/315384
published in The Journal of Infectious Diseases 181(4), 1359-1363 (Oxford University Press)
openalex publication_date 2000/04/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
The seroprevalence of Helicobacter pylori infection was examined in the adult US population and among different ethnic groups. Stored sera from 7465 adult participants in the first phase of the third National Health and Nutritional Examination Survey (1988-1991) were tested with a sensitive and specific IgG ELISA, to diagnose infection. Seroprevalence of H. pylori among all participants was 32. 5%. This increased with age, from 16.7% for persons 20-29 years old to 56.9% for those > or =70 years old. Age-adjusted prevalence was substantially higher among non-Hispanic blacks (52.7%) and Mexican Americans (61.6%) than among non-Hispanic whites (26.2%). After controlling for age and other associated factors, the odds ratios relative to non-Hispanic whites decreased for non-Hispanic blacks, from 3.9 (95% confidence interval [CI], 3.1-4.9) to 3.3 (95% CI, 2. 6-4.2), and for Mexican Americans, from 6.3 (95% CI, 4.8-8.3) to 2.3 (95% CI, 1.6-3.5). The high prevalence of H. pylori infection among non-Hispanic blacks and Mexican Americans is partially explained by other factors associated with infection.