2002/07/26 by Jafar Mahdavi, Berit Sondén, Marina Hurtig +20 · 4 citations
Medicine · Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Helicobacter pylori-related gastroenterology studies #Galectins and Cancer Biology #Glycosylation and Glycoproteins Research #Bacterial adhesin #Helicobacter pylori #Glycoconjugate #Microbiology #Virulence #Inflammation #Biology #Sialic acid #Antigen #Immunology #Receptor #Gastric mucosa #Virulence factor #Gene #Stomach #Genetics #Biochemistry
paper · doi:10.1126/science.1069076
openalex publication_date 2002/07/26 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.