2007/04/12 by Ryan D. Hernandez, Melissa J. Hubisz, David A. Wheeler +11 · 3 citations
Psychology · Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Primate Behavior and Ecology #Animal Behavior and Reproduction #Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities #Linkage disequilibrium #Rhesus macaque #Biology #Coalescent theory #Macaque #Genetics #Demographic history #Population #Evolutionary biology #Disequilibrium #Haplotype #Demography #Genetic variation #Gene #Phylogenetics #Allele
paper · doi:10.1126/science.1140462
openalex publication_date 2007/04/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.