Myocardial Reperfusion Injury

2007/09/13 by Derek M. Yellon, Derek J. Hausenloy · 3 citations
Medicine · #Cardiac Ischemia and Reperfusion #Cardiac Arrest and Resuscitation #Cardiac electrophysiology and arrhythmias #Medicine #Cardioprotection #Myocardial Reperfusion Injury #Percutaneous coronary intervention #Reperfusion injury #Cardiology #Myocardial ischemia #Internal medicine #Blood flow #Ischemic reperfusion injury #Ischemia #Myocardial infarction

paper · doi:10.1056/nejmra071667

openalex publication_date 2007/09/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of the injury, on attempts to protect the heart against it, and on promising new approaches to cardioprotection during percutaneous coronary intervention.

Cited by

• Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations
• Remote Ischemic Conditioning in Emergency Medicine—Clinical Frontiers and Research Opportunities
• Thrombosis [wikipedia]

Related

• Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations
• Mechanically Unloading the Left Ventricle Before Coronary Reperfusion Reduces Left Ventricular Wall Stress and Myocardial Infarct Size
• Reduction of Myocardial Infarct Size with Ischemic “Conditioning”
• Pathophysiology, prevention, and management of coronary microvascular obstruction
• Pathophysiology of coronary artery disease leading to acute coronary syndromes