2002/04/01 by Jan Lind, Henk C.S. Wallenburg · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Connective tissue disorders research #Pelvic floor disorders treatments #Tendon Structure and Treatment #Ehlers–Danlos syndrome #Medicine #Retrospective cohort study #Pregnancy #Obstetrics #Gestation #Population #Pediatrics #Surgery
paper · doi:10.1034/j.1600-0412.2002.810403.x
openalex publication_date 2002/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
BACKGROUND: The study was carried out to assess the course and outcome of pregnancies in women with the Ehlers-Danlos syndrome, with the aim of developing guidelines for assessment of risk and counseling, and for providing optimum medical and obstetric care. METHODS: A retrospective study based on data collected from members of the Dutch Association of Ehlers-Danlos patients. Pregnancies and neonatal outcomes of the affected mothers were compared with those of the nonaffected mothers who delivered an infant with Ehlers-Danlos syndrome. RESULTS: In a group of 46 women with Ehlers-Danlos syndrome, 128 pregnancies beyond 24 weeks gestation were evaluated and compared with 43 pregnancies of 33 nonaffected women. The main maternal complications consisted of pelvic pain and instability (26% vs. 7%). One bowel rupture was reported in a woman with Ehlers-Danlos syndrome type IV. Preterm delivery occurred in 21% of the affected mothers compared with 40% of the nonaffected women with an affected infant; the women with Ehlers-Danlos syndrome experienced postpartum hemorrhage (19% vs. 7%) and complicated perineal wounds (8% vs. 0%) more often than the unaffected women. The floppy infant syndrome was diagnosed in 13% of the affected infants and did not occur in the nonaffected neonates. CONCLUSION: Pregnancy is generally well-tolerated in women with Ehlers-Danlos syndrome, with favorable maternal and neonatal outcomes. In Ehlers-Danlos syndrome type IV it may be associated with severe maternal complications. Preconceptional counseling concerning specific possible complications and a multidisciplinary approach are recommended.