Hypermobile Ehlers–Danlos syndrome (a.k.a. Ehlers–Danlos syndrome Type III and Ehlers–Danlos syndrome hypermobility type): Clinical description and natural history

2017/02/01 by Brad T. Tinkle, Marco Castori, Britta Berglund +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Connective tissue disorders research #Dermatological and Skeletal Disorders #Child Abuse and Related Trauma #Ehlers–Danlos syndrome #Joint hypermobility #Hypermobility (travel) #Connective Tissue Disorder #Medicine #Natural history #Dermatology #Connective tissue #Nosology #Pathology #Physical therapy #Internal medicine

paper · pdf · doi:10.1002/ajmg.c.31538

openalex publication_date 2017/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

The hypermobile type of Ehlers-Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue. It has been described largely in those with musculoskeletal complaints including joint hypermobility, joint subluxations/dislocations, as well as skin and soft tissue manifestations. Many patients report activity-related pain and some go on to have daily pain. Two undifferentiated syndromes have been used to describe these manifestations-joint hypermobility syndrome and hEDS. Both are clinical diagnoses in the absence of other causation. Current medical literature further complicates differentiation and describes multiple associated symptoms and disorders. The current EDS nosology combines these two entities into the hypermobile type of EDS. Herein, we review and summarize the literature as a better clinical description of this type of connective tissue disorder. © 2017 Wiley Periodicals, Inc.

Citations

• Functional Digestive Symptoms and Quality of Life in Patients with Ehlers-Danlos Syndromes: Results of a National Cohort Study on 134 Patients
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Cited by

• Ehlers–Danlos syndrome [wikipedia]

Related

• Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations
• The 2017 international classification of the Ehlers–Danlos syndromes
• Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: a national electronic cohort study and case–control comparison
• The Ehlers–Danlos syndromes, rare types
• Ehlers-Danlos Syndrome in Orthopaedics