2013/01/04 by S F Cotmore, Peter Tattersall · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Medicine · #Animal Virus Infections Studies #Biology #Cell biology #Control of chromosome duplication #DNA #DNA re-replication #DNA replication #Duplex (building) #Eukaryotic DNA replication #Gene #Genetics #Genome #Origin of replication #Origin recognition complex #Parvovirus #Parvovirus B19 Infection Studies #Telomere #Virus #Virus-based gene therapy research
paper · pdf · doi:10.1101/cshperspect.a012989
openalex publication_date 2013/01/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14
Parvoviruses have a linear single-stranded DNA genome, around 5 kb in length, with short imperfect terminal palindromes that fold back on themselves to form duplex hairpin telomeres. These contain most of the cis-acting information required for viral "rolling hairpin" DNA replication, an evolutionary adaptation of rolling-circle synthesis in which the hairpins create duplex replication origins, prime complementary strand synthesis, and act as hinges to reverse the direction of the unidirectional cellular fork. Genomes are packaged vectorially into small, rugged protein capsids ~260 Å in diameter, which mediate their delivery directly into the cell nucleus, where they await their host cell's entry into S phase under its own cell cycle control. Here we focus on genus-specific variations in genome structure and replication, and review host cell responses that modulate the nuclear environment.