1988/02/01 by Pierre Druilhe, O Brandicourt, T Chongsuphajaisiddhi +1 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · Chemistry · #Malaria Research and Control #Traditional and Medicinal Uses of Annonaceae #Quinazolinone synthesis and applications #Quinidine #Cinchonine #Quinine #Cinchonidine #Plasmodium falciparum #Cinchona Alkaloids #Cinchona #Alkaloid #Chemistry #Bark (sound) #In vitro #Pharmacology #Biology #Stereochemistry #Biochemistry #Malaria #Enantioselective synthesis #Catalysis
paper · doi:10.1128/aac.32.2.250
openalex publication_date 1988/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
In vitro studies with quinine, quinidine, cinchonine, and cinchonidine showed that despite a similarity of chemical structure, the effectiveness of these cinchona bark alkaloids against several culture lines of Plasmodium falciparum varied widely. Depending on the strain tested, quinidine and cinchonine were 1 to 10 and 1 to 5 times, respectively, more active than quinine. A combination made of equal parts of quinine, quinidine, and cinchonine was found to have several interesting features; it had activity similar to that of quinine against quinine-susceptible strains but was found to be 2 to 10 times more effective against strains resistant to quinine and had a more consistent effect than any of the alkaloids used singly. The potentiation was found to depend mainly on the presence of cinchonine in the mixtures studied. Synergism was also confirmed in a study of 25 P. falciparum strains isolated from Thai patients. Combinations of cinchona bark alkaloids could thus be of interest in areas where P. falciparum is becoming less susceptible to quinine.