1983/06/01 by Thomas Eisner, Scott Camazine · 3 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Healthcare and Venom Research #Venomous Animal Envenomation and Studies #Insect and Pesticide Research #Venom #Autotomy #Spider #Envenomation #Biology #Predation #Melittin #Histamine #Insect #Zoology #Toxicology #Pharmacology #Ecology #Biochemistry
paper · doi:10.1073/pnas.80.11.3382
openalex publication_date 1983/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
Field observations showed orb-weaving spiders (Argiope spp.) to undergo leg autotomy if they are stung in a leg by venomous insect prey (Phymata fasciata). The response occurs within seconds, before the venom can take lethal action by spread to the body of the spiders. Autotomy is induced also by honeybee venom and wasp venom, as well as by several venom components (serotonin, histamine, phospholipase A(2), melittin) known to be responsible for the pain characteristically elicited by venom injection in humans. The sensing mechanism by which spiders detect injected harmful chemicals such as venoms therefore may be fundamentally similar to the one in humans that is coupled with the perception of pain.