2004/04/01 by A. S. Hill, Jonathan Werner, Quinton R. Rogers +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Biochemical Acid Research Studies #Metabolism and Genetic Disorders #Electrolyte and hormonal disorders #CATS #Toxicity #Lipoic acid #Antioxidant #Chemistry #Pharmacology #Acute toxicity #Medicine #Internal medicine #Biochemistry
paper · doi:10.1111/j.1439-0396.2003.00472.x
openalex publication_date 2004/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/23
The antioxidant lipoic acid (LA) is administered to humans and pets. We described acute toxicity and maximum tolerated dose (MTD) of LA in cats. In progression, 10 healthy adult male cats received orally 60 (high), 30 (low), or 0 mg LA/kg (control). Serum enzyme activities and concentrations of bile acids, ammonia, amino acids (AA), LA and dihydrolipoic acid (DHLA) were measured, and tissues examined microscopically. Significant clinical toxicity with changes in ammonia and AA concentrations occurred in all high-dose cats. Oral LA produced hepatocellular toxicity and MTD was < 30 mg/kg in cats.