2017/06/30 by Chaoran Ma, Yesong Liu, Samantha Neumann +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · Nursing · Medicine · Psychology · #Nicotinic Acetylcholine Receptors Study #Olfactory and Sensory Function Studies #Biochemical Analysis and Sensing Techniques #Nicotine #Medicine #Parkinson's disease #Disease #Dopaminergic #Clinical trial #Epidemiology #Smoking cessation #Levodopa #Neurology #Pharmacology #Animal studies #Psychiatry #Dopamine #Neuroscience #Internal medicine #Psychology #Pathology
paper · pdf · doi:10.1186/s40035-017-0090-8
openalex publication_date 2017/06/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease (PD). As a major component of tobacco smoke, nicotine has been proposed to be a substance for preventing against PD risk, with a key role in regulating striatal activity and behaviors mediated through the dopaminergic system. Animal studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced dyskinesias. However, previous clinical trials yield controversial results regarding nicotine treatment. In this review, we updated epidemiological, preclinical and clinical data, and studies on nicotine from diet. We also reviewed interactions between genetic factors and cigarette smoking. As a small amount of nicotine can saturate a substantial portion of nicotine receptors in the brain, nicotine from other sources, such as diet, could be a promising therapeutic substance for protection against PD.