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Wright and Fisher on Inbreeding and Random Drift

2010/03/01 by James F. Crow · 1 citation
Biochemistry, Genetics and Molecular Biology · Mathematics · #Genetic diversity and population structure #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock #Inbreeding #Wright #Biology #Genetic drift #Evolutionary biology #Population #Genetics #Statistics #Demography #Mathematics #Gene #Sociology #Genetic variation #History

paper · pdf · doi:10.1534/genetics.109.110023

openalex publication_date 2010/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

Sewall Wright and R. A. Fisher often differed, including on the meaning of inbreeding and random gene frequency drift. Fisher regarded them as quite distinct processes, whereas Wright thought that because his inbreeding coefficient measured both they should be regarded as the same. Since the effective population numbers for inbreeding and random drift are different, this would argue for the Fisher view.

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