2019/06/28 by Emily Lehmann Levin · 1 citation
Medicine · #Migraine and Headache Studies #Trigeminal Neuralgia and Treatments #Ophthalmology and Eye Disorders #Cluster headache #Medicine #Triptans #Verapamil #Anesthesia #Topiramate #Irritability #Migraine #Epilepsy #Internal medicine
paper · doi:10.1093/med/9780190887674.003.0016
openalex publication_date 2019/06/28 · openalex created_date 2022/05/12 · openalex updated_date 2026/05/21
Cluster headache, a trigeminal autonomic cephalgia, is a syndrome involving unilateral head pain associated with autonomic symptoms. The diagnosis is clinical. The pathophysiology of cluster headache is unknown. It is believed to involve the trigeminal nerve and ganglion, with autonomic dysfunction and vascular irritability. Initial treatment is with parenteral triptans and inhaled oxygen. Preventive agents include topiramate, verapamil, and lithium. Occipital nerve blocks and stimulation have been effective in small studies. Surgery is limited to those patients that have persistent, chronic cluster headache with a minimum of three attacks per week, despite treatment with at least three preventative agents. Deep brain stimulation of the posterior hypothalamus has been shown to be effective in the treatment of chronic cluster headache.