A Simple, Rapid Method for the Preparation of [11C]Formaldehyde

2008/07/05 by Jacob M. Hooker, Matthias Schönberger, Hanno Schieferstein +1 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · Chemistry · #Medical Imaging Techniques and Applications #Radiopharmaceutical Chemistry and Applications #Cancer, Hypoxia, and Metabolism #Formaldehyde #Reagent #Chemistry #Trimethylamine #Methyl iodide #Molecule #Radiochemistry #Organic chemistry #Inorganic chemistry #Combinatorial chemistry

paper · doi:10.1002/anie.200800991

openalex publication_date 2008/07/05 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28

Abstract

A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules—[11C]formaldehyde—is accessible from [11C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. Easy access to [11C]formaldehyde expands the scope of the carbon-11 toolbox and will lead to new reaction methodology and imaging compounds.

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• Formaldehyde [wikipedia]

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