2015/08/11 by J. Paul Bolam, Tommas J. Ellender · 1 citation
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · Medicine · #Mast cells and histamine #Receptor Mechanisms and Signaling #Neurotransmitter Receptor Influence on Behavior #Histaminergic #Basal ganglia #Neuroscience #Histamine #Histamine H3 receptor #Striatum #Indirect pathway of movement #Wakefulness #Biology #Psychology #Receptor #Central nervous system #Dopamine #Endocrinology #Medicine #Internal medicine #Antagonist
paper · pdf · doi:10.1016/j.neuropharm.2015.08.013
openalex publication_date 2015/08/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/02
The neuromodulator histamine is released throughout the brain during periods of wakefulness. Combined with an abundant expression of histamine receptors, this suggests potential widespread histaminergic control of neural circuit activity. However, the effect of histamine on many of these circuits is unknown. In this review we will discuss recent evidence for histaminergic modulation of the basal ganglia circuitry, and specifically its main input nucleus; the striatum. Furthermore, we will discuss recent findings of histaminergic dysfunction in several basal ganglia disorders, including in Parkinson's disease and most prominently, in Tourette's syndrome, which has led to a resurgence of interest in this neuromodulator. Combined, these recent observations not only suggest a central role for histamine in modulating basal ganglia activity and behaviour, but also as a possible target in treating basal ganglia disorders. This article is part of the Special Issue entitled 'Histamine Receptors'.