Penicillin allergy: A practical guide for clinicians

2015/05/01 by Alexei Gonzalez‐Estrada, Cristine Radojicic · 1 citation
Medicine · #Drug-Induced Adverse Reactions #Food Allergy and Anaphylaxis Research #Urticaria and Related Conditions #Medicine #Penicillin allergy #Penicillin #Desensitization (medicine) #Allergy #Immunology #Intensive care medicine #Antibiotics #Internal medicine #Microbiology

paper · pdf · doi:10.3949/ccjm.82a.14111

openalex publication_date 2015/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as 'penicillin-allergic' are able to tolerate penicillin. Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization. Cross-reactivity between penicillin and other beta-lactams is less common than previously thought.

Citations

• Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003

Cited by

• Allergy [wikipedia]

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