2017/04/11 by Roxanne Toivanen, Michael M. Shen · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Prostate Cancer Treatment and Research #Prostate Cancer Diagnosis and Treatment #Hippo pathway signaling and YAP/TAZ #Organogenesis #Biology #Mesenchyme #Prostate #Morphogenesis #Prostate cancer #Hormone #Carcinogenesis #Cell biology #Endocrinology #Cancer #Genetics #Mesenchymal stem cell #Gene
paper · pdf · doi:10.1242/dev.148270
openalex publication_date 2017/04/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.