2019/12/18 by Göksel Güven, Goksel Guven, Matthias P. Hilty +3 · 240 citations
Medicine · Neuroscience · #Bench to bedside #Biology #Disease #Hemodynamic Monitoring and Therapy #Intensive care medicine #Internal medicine #Medical physics #Medicine #Microcirculation #Neuroscience #Organ system #Pathology #Physiology #Resuscitation #Sepsis Diagnosis and Treatment #Shock (circulatory) #Surgery #Trauma, Hemostasis, Coagulopathy, Resuscitation
paper · pdf · doi:10.1159/000503775
published in Blood Purification 49(1-2), 143-150 (S. Karger AG)
crossref issued 2019/12/18 · crossref published 2019/12/18 · crossref published-online 2019/12/18 · openalex publication_date 2019/12/18 · crossref created 2019/12/18 · crossref published-print 2020/01/01 · crossref deposited 2025/04/23 · openalex created_date 2025/10/10 · crossref indexed 2026/08/01 · openalex updated_date 2026/08/01
This paper briefly reviews the physiological components of the microcirculation, focusing on its function in homeostasis and its central function in the realization of oxygen transport to tissue cells. Its pivotal role in the understanding of circulatory compromise in states of shock and renal compromise is discussed. Our introduction of hand-held vital microscopes (HVM) to clinical medicine has revealed the importance of the microcirculation as a central target organ in states of critical illness and inadequate response to therapy. Technical and methodological developments have been made in hardware and in software including our recent introduction and validation of automatic analysis software called MicroTools, which now allows point-of-care use of HVM imaging at the bedside for instant availability of functional microcirculatory parameters needed for microcirculatory targeted resuscitation procedures to be a reality.