Valencian Gulf offer deadline nears. I. [April 30, 1976]

1976/03/29 by Yousuke Tsuneoka, Teppo Maruyama, Sachine Yoshida +5 · 26 citations
Earth and Planetary Sciences · Medicine · Neuroscience · Psychology · #Biology #GABAergic #Geological and Geophysical Studies Worldwide #Geology #Glutamate receptor #Glutamatergic #Humanities #Hypothalamic control of reproductive hormones #Hypothalamus #Inhibitory postsynaptic potential #Neurochemical #Neuroendocrine regulation and behavior #Neuroscience #Neuroscience of respiration and sleep #Ocean Acidification Effects and Responses #Petroleum engineering #Preoptic area #Valencian

paper · doi:10.1002/cne.23251

published in Oil & gas journal/Oil and gas journal 521(7), 1633-63 (PennWell)

openalex publication_date 1976/03/29 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/13

Abstract

In rodents, previous findings indicate critical involvement of the medial preoptic area (MPOA) in the neural control of maternal behavior. However, the specification of the particular MPOA subregions involved in maternal behavior and the identification of the neurochemical phenotype(s) of the essential neurons demands additional study. Therefore, we investigated the chemical neuroanatomy of the essential MPOA subregion for maternal behavior in C57BL/6J female mice. Using the oxytocinergic neurons in the dorsal MPOA as a primary regional marker, we first assessed the distribution of c-Fos-expressing neurons in the MPOA during maternal behavior using immunohistochemistry. Results showed that non-oxytocinergic neurons in the dorsal and ventral MPOA prominently expressed c-Fos during maternal behavior. Then using excitotoxic lesion studies, we determined the specific MPOA area that is necessary for maternal behavior. Bilateral lesions of the central MPOA, where c-Fos was expressed only moderately, effectively disrupted maternal behavior, although lesions to the dorsal and ventral MPOA regions were ineffective. These centrally lesioned females were highly infanticidal irrespective of their previous maternal experience. Neurochemical investigations showed that more than 75% of the c-Fos-expressing neurons in central MPOA were GABAergic. Many of them also expressed galanin, neurotensin, and/or tachykinin2 mRNAs. Finally, the central MPOA was populated by numerous glutamatergic neurons, although only a small percentage of these neurons colocalized with c-Fos. To conclude, the central MPOA is the indispensable subregion for mouse maternal behavior, and GABAergic and/or peptidergic neurons in this area were transcriptionally activated during maternal behavior.

Citations

• Estrogen configures sexual dimorphism in the preoptic area of C57BL/6J and ddN strains of mice
• Effect of preoptic region implants of dilute estradiol on the maternal behavior of ovariectomized, nulliparous rats
• Comparative distribution of estrogen receptor-? and -? mRNA in the rat central nervous system

Cited by

• A prolactin-receptive neural circuit drives maternal interactions with pups in mice
• Behavioral transition from attack to parenting in male mice: a crucial role of the vomeronasal system. [europepmc]
• Characterization of GABAergic neurons in the mouse lateral septum: a double fluorescence in situ hybridization and immunohistochemical study using tyramide signal amplification. [europepmc]
• Genes showing altered expression in the medial preoptic area in the highly social maternal phenotype are related to autism and other disorders with social deficits. [europepmc]
• Maternally responsive neurons in the bed nucleus of the stria terminalis and medial preoptic area: Putative circuits for regulating anxiety and reward. [europepmc]
• Neural mechanisms of mother-infant bonding and pair bonding: Similarities, differences, and broader implications. [europepmc]
• Common and divergent psychobiological mechanisms underlying maternal behaviors in non-human and human mammals. [europepmc]
• Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice. [europepmc]
• The neural circuits of mating and fighting in male mice. [europepmc]
• Moxd1 Is a Marker for Sexual Dimorphism in the Medial Preoptic Area, Bed Nucleus of the Stria Terminalis and Medial Amygdala. [europepmc]
• Freezing suppression by oxytocin in central amygdala allows alternate defensive behaviours and mother-pup interactions. [europepmc]
• Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse. [europepmc]
• Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender. [europepmc]
• A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors. [europepmc]
• Thalamic integration of social stimuli regulating parental behavior and the oxytocin system. [europepmc]
• Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region. [europepmc]
• AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building. [europepmc]
• The parental brain and behavior: A target for endocrine disruption. [europepmc]
• Reorganization of perineuronal nets in the medial Preoptic Area during the reproductive cycle in female rats. [europepmc]
• Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice. [europepmc]
• Modified in situ Hybridization Chain Reaction Using Short Hairpin DNAs. [europepmc]
• Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior. [europepmc]
• Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice. [europepmc]
• A hypothalamic pathway that suppresses aggression toward superior opponents. [europepmc]
• The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections. [europepmc]
• Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy. [europepmc]

Related

• A prolactin-receptive neural circuit drives maternal interactions with pups in mice
• Sexually dimorphic oxytocin receptor‐expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior
• Vasopressin-to-oxytocin receptor crosstalk in the preoptic area underlying parental behaviors in male mice
• Oxytocin-Dopamine Interactions Mediate Variations in Maternal Behavior in the Rat
• The density of doublecortin cells in the piriform cortex is affected by transition to adulthood but not first pregnancy in mice