2016/10/06 by Klaus Lehnertz, Henning Dickten · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #q-bio.NC #physics.med-ph
paper · pdf · doi:10.1098/rsta.2014.0094
published as Phil. Trans. R. Soc. A 373, 2034 (2015)
arxiv created 2016/10/06 · arxiv updated 2016/10/07
Inferring strength and direction of interactions from electroencephalographic (EEG) recordings is of crucial importance to improve our understanding of dynamical interdependencies underlying various physiologic and pathophysiologic conditions in the human epileptic brain. We here use approaches from symbolic analysis to investigate---in a time-resolved manner---weighted and directed, short- to long-ranged interactions between various brain regions constituting the epileptic network. Our observations point to complex spatial-temporal interdependencies underlying the epileptic process and their role in the generation of epileptic seizures, despite the massive reduction of the complex information content of multi-day, multi-channel EEG recordings through symbolisation. We discuss limitations and potential future improvements of this approach.