2015/09/09 by Lorena Ruiz-Perez, Lorena Ruiz‐Pérez, Léa Messager +6 · 86 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · Materials Science · Mathematics · Physics and Astronomy · #Advanced Polymer Synthesis and Characterization #Amphiphile #Biology #Computational biology #Computer science #Copolymer #Engineering #Lipid Membrane Structure and Behavior #Materials science #Mathematics #Nanotechnology #Polymer Surface Interaction Studies #Polymersome #Surface (topology) #Topology (electrical circuits) #cond-mat.soft #physics.bio-ph
paper · pdf · doi:10.1126/sciadv.1500948
published in Science Advances 2(4), e1500948 (American Association for the Advancement of Science) · 11 pages, 4 Figures plus supporting information
arxiv created 2015/09/09 · openalex publication_date 2016/04/01 · arxiv updated 2016/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Biological systems exploit self-assembly to create complex structures whose arrangements are finely controlled from the molecular to mesoscopic level. We report an example of using fully synthetic systems that mimic two levels of self-assembly. We show the formation of vesicles using amphiphilic copolymers whose chemical nature is chosen to control both membrane formation and membrane-confined interactions. We report polymersomes with patterns that emerge by engineering interfacial tension within the polymersome surface. This allows the formation of domains whose topology is tailored by chemical synthesis, paving the avenue to complex supramolecular designs functionally similar to those found in viruses and trafficking vesicles.