Granulomatous inflammation--a review.

1983/07/01 by G T Williams, Geraint T. Williams, W J Williams +1 · 330 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #Chronic granulomatous disease #Epithelioid cell #Fibrosis #Giant cell #Granuloma #Granulomatous inflammation #Immune system #Immunohistochemistry #Immunology #Inflammasome and immune disorders #Inflammation #Macrophage #Macrophage Migration Inhibitory Factor #Medicine #Mononuclear phagocyte system #Multinucleate #Parasites and Host Interactions #Pathology #Phagocyte

paper · pdf · doi:10.1136/jcp.36.7.723

published in Journal of Clinical Pathology 36(7), 723-733 (BMJ)

openalex publication_date 1983/07/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

The granulomatous inflammatory response is a special type of chronic inflammation characterised by often focal collections of macrophages, epithelioid cells and multinucleated giant cells. In this review the characteristics of these cells of the mononuclear phagocyte series are considered, with particular reference to the properties of epithelioid cells and the formation of multinucleated giant cells. The initiation and development of granulomatous inflammation is discussed, stressing the importance of persistence of the inciting agent and the complex role of the immune system, not only in the perpetuation of the granulomatous response but also in the development of necrosis and fibrosis.

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