2014/04/02 by Sang Yun Ha, Juyoun Shin, Jeong Hoon Kim +7 · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Angiogenesis and VEGF in Cancer #Bioinformatics #Biology #Cancer #Cancer research #Cell Adhesion Molecules Research #Colorectal cancer #HER2/EGFR in Cancer Research #Integrin #Internal medicine #Medicine #Oncology #Receptor
paper · doi:10.1136/jclinpath-2013-202163
openalex publication_date 2014/04/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
AIMS: Integrin αv subunits are involved in tumour angiogenesis and tumour progression in various types of cancers. Clinical trials evaluating agents targeting integrin αv are ongoing. Integrin αv expression has been reported in several cancers in association with tumour progression or poor survival. However, no study has addressed the prognostic influence of integrin αv expression on survival of patients with colorectal cancer (CRC). METHODS: Immunohistochemical staining of integrin αv was performed in 198 CRC samples to evaluate its prognostic significance. RESULTS: High expression of integrin αv was observed in 58.1% (115/189) of colorectal adenocarcinoma samples, while only in 11.5% (3/26) of tubular adenoma samples and in none of normal mucosa or hyperplastic polyp samples. It was more frequently found in female patients and less frequently observed in well differentiated tumours. The proportion of cases with high expression of integrin αv showed an increasing trend with increased T stage (p=0.032), N stage (p=0.006) and TNM stage (p=0.001). Patients displaying exuberant expression of integrin αv showed shorter overall survival (p=0.001) and disease-free survival (p=0.004). Elevated integrin αv expression was an independent prognostic factor for overall survival (HR: 2.04, 95% CI 1.16 to 3.56; p=0.013) and disease-free survival (HR: 2.19, 95% CI 1.16 to 4.13; p=0.015). CONCLUSIONS: Overexpression of integrin αv is associated with advanced T and N stage and as an independent prognostic factor in CRC.