The trichodysplasia spinulosa‐associated polyomavirus: virological background and clinical implications

2013/04/18 by Siamaque Kazem, Els van der Meijden, Mariet C.W. Feltkamp · 5 citations
Medicine · Engineering · Agricultural and Biological Sciences · #Polyomavirus and related diseases #Antenna Design and Analysis #Plant Virus Research Studies

paper · pdf · doi:10.1111/apm.12092

openalex publication_date 2013/04/18 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/29

Abstract

Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a new species of the family Polyomaviridae that was discovered in 2010. TSPyV infects humans and is associated with the development of a rare disease called trichodysplasia spinulosa. Trichodysplasia spinulosa is a skin disease of severely immunocompromised hosts characterized by follicular distention and keratotic spine formation especially on the face. Electron microscopy, immunohistochemistry, and viral load measurements indicate an etiological role of active TSPyV infection in the development of this disease. This review will address virological and pathogenic properties of TSPyV, as well as epidemiologic, diagnostic, and therapeutic aspects of TSPyV infection.

Citations

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Cited by

• Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma
• The human polyomaviruses: from orphans and mutants to patchwork family
• Molecular insight into the viral biology and clinical features of trichodysplasia spinulosa
• Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21
• Trichodysplasia spinulosa polyomavirus [wikipedia]

Related

• Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient
• Molecular insight into the viral biology and clinical features of trichodysplasia spinulosa
• Seroprevalence of Trichodysplasia Spinulosa–associated Polyomavirus
• Viral-Associated Trichodysplasia
• Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21