Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma

1994/12/16 by Yuan Chang, Ethel Cesarman, Melissa S. Pessin +4 · 7 citations
Medicine · #Viral-associated cancers and disorders #Cytomegalovirus and herpesvirus research #Lymphoma Diagnosis and Treatment

paper · doi:10.1126/science.7997879

openalex publication_date 1994/12/16 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/03

Abstract

Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.

Citations

• Basic local alignment search tool

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