2005/04/08 by Esben Skovsen, John W. Snyder, John D. C. Lambert +1 · 2 citations
Medicine · Engineering · Materials Science · #Photodynamic Therapy Research Studies #Nanoplatforms for cancer theranostics #Porphyrin and Phthalocyanine Chemistry
paper · doi:10.1021/jp051163i
openalex publication_date 2005/04/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
In time- and spatially resolved experiments, singlet molecular oxygen, O(2)(a(1)Delta(g)), was created in a single nerve cell upon irradiation of a sensitizer incorporated in the cell nucleus using a focused laser beam. The singlet oxygen thus produced was detected by its infrared phosphorescence. Data obtained indicate that, contrary to common perception, this reactive species can be quite long-lived in a cell and, as such, can diffuse over appreciable distances including across the cell membrane into the extra-cellular environment. These results provide a new perspective for mechanistic studies of photoinduced cell death and intracellular signaling.