2015/07/03 by Wieland Marth, Sebastian Aland, Axel Voigt · 44 citations
Engineering · Medicine · Physics and Astronomy · #Blood properties and coagulation #Breakup #Dependency (UML) #Field (mathematics) #Inertia #Inertial frame of reference #Lattice Boltzmann Simulation Studies #Lift (data mining) #Mesoscopic physics #Platelet Disorders and Treatments #Reynolds number #physics.bio-ph #physics.flu-dyn
paper · pdf · doi:10.1017/jfm.2016.15
published in Journal of Fluid Mechanics 790, 389-406 (Cambridge University Press)
arxiv created 2015/07/03 · openalex publication_date 2016/02/03 · arxiv updated 2016/04/20 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
We numerically investigate margination of white blood cells and demonstrate the dependency on a number of conditions including haematocrit, the deformability of the cells and the Reynolds number. The approach, which is based on a mesoscopic hydrodynamic Helfrich-type model, reproduces previous results, e.g. a decreasing tendency for margination with increasing deformability and a non-monotonic dependency on haematocrit. The consideration of inertia effects, which may be of relevance in various parts of the cardiovascular system, indicates a decreasing tendency for margination with increasing Reynolds number. The effect is discussed by analysing inertial and non-inertial lift forces for single cells under different flow conditions and large-scale two-dimensional simulations of interacting red blood cells and white blood cells in an idealized blood vessel.