Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies

2015/03/19 by Tana Omokoko, Petra Simon, Özlem Türeci +1 · 1 citation
Medicine · Immunology and Microbiology · #CAR-T cell therapy research #T-cell and B-cell Immunology #Immune Cell Function and Interaction

paper · pdf · doi:10.1080/2162402x.2015.1005523

openalex publication_date 2015/03/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only broadens the diversity of TCRs suitable for clinical use, but also sets the stage for actively personalized immunotherapeutic strategies.

Citations

• Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

Cited by

• Özlem Türeci [wikipedia]

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