2004/11/01 by Walter R. Vandaveer, Stephanie Pasas-Farmer, David J. Fischer +2 · 1 citation
Chemistry · Engineering · #Amperometry #Analyte #Capillary electrophoresis #Chemistry #Chromatography #Computer science #Electrochemistry #Electrode #Engineering #Innovative Microfluidic and Catalytic Techniques Innovation #Lab-on-a-chip #Materials science #Microfluidic and Capillary Electrophoresis Applications #Microfluidics #Nanotechnology #Process engineering #Software portability
paper · doi:10.1002/elps.200406115
openalex publication_date 2004/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Significant progress in the development of miniaturized microfluidic systems has occurred since their inception over a decade ago. This is primarily due to the numerous advantages of microchip analysis, including the ability to analyze minute samples, speed of analysis, reduced cost and waste, and portability. This review focuses on recent developments in integrating electrochemical (EC) detection with microchip capillary electrophoresis (CE). These detection modes include amperometry, conductimetry, and potentiometry. EC detection is ideal for use with microchip CE systems because it can be easily miniaturized with no diminution in analytical performance. Advances in microchip format, electrode material and design, decoupling of the detector from the separation field, and integration of sample preparation, separation, and detection on-chip are discussed. Microchip CEEC applications for enzyme/immunoassays, clinical and environmental assays, as well as the detection of neurotransmitters are also described.