1988/12/01 by Beverly A. Mock, Carol A. Nacy · 2 citations
Medicine · Agricultural and Biological Sciences · #Research on Leishmaniasis Studies #Trypanosoma species research and implications #Insect and Pesticide Research
paper · pdf · doi:10.1128/iai.56.12.3316-3319.1988
openalex publication_date 1988/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
Differences in susceptibility to intravenously inoculated Leishmania major were observed in male and female mice of the BALB/cAnPt, DBA/2N, and DBA/2J strains and (BALB/cAnPt x DBA/2N)F1 hybrids. In all cases, males had significantly higher liver parasite burdens than females. Orchidectomy of BALB/c males resulted in a 20% decrease in the number of parasites in the liver compared with either normal or sham-gonadectomized controls. Additionally, testosterone treatment of female BALB/c mice resulted in an 88% increase in the number of liver amastigotes. These results suggest that the hormone testosterone can modulate systemic L. major infections in BALB/c mice.